Process Chemistry
This section summarizes my experience and capabilities in process chemistry.
Although my practical experience falls within the perimeter of what can be
described as
early process chemistry, this is not a self-limiting
factor. Designing process friendly synthetic routes can be an enjoyable
exercise. The stepwise incremental optimization of reaction parameters is an
area which is familiar.
I have solved problems in early process chemistry, whenever the opportunity
has been presented to me. Examples of practical experience in this field
include regiospecific reduction of a nitro group in the presence of a
neighbouring nitrile, optimization of a given route for the synthesis of a
carbocyclic nucleoside and synthesis of a serine derivative;
click to view and download a process friendly route for the synthesis of
puleganic acid.
Purification and crystallization of process intermediates is a related area
where success has accompanied me. I have had the pleasure of turning
'goo' into crystals on many occasions.
Last, but not least I offer the ability to independently contribute toward
the improvement of existing routes which may not be safe or economical.
The
Innocentive award
corresponding to the challenge "Synthesis of a Lactic
Acid Ester" resulted from presenting a solution to a problem which had to be
solved within the constraints of process chemistry.
Are you interested in an efficient and scalable synthesis of
1,2-pentanediol?
A proposal document is available outlining single and two-step syntheses
of 1,2-pentanediol. This material is used in the formulation of cosmetics
and as a solvent for printing inks.
Please
contact me if you
need additional information or need to
solve a problem.
